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抗苗勒氏管激素(anti-Müllerian hormone,AMH)又称为苗勒管抵制物(Müllerian-inhibiting substance,MIS),是转化生长因子β(transforming growth factor,TGF-β)超家族的成员。AMH具有良好的稳定性,一般情况下在整个月经周期中无明显波动,但是仍有一些因素影响AMH的分泌水平,这些变化在临床中有着重要的意义和价值。本文从多囊卵巢综合征、年龄、肥胖、季节、卵巢储备和性分化异常等6个方面总结了可能引起AMH变化的因素,从而深入认识AMH变化的临床意义和价值。
Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance (MIS), is a member of the transforming growth factor-β (TGF-β) superfamily. AMH has a good stability, generally no significant fluctuations in the menstrual cycle, but there are still some factors that affect the secretion of AMH, these changes have clinical significance and value. This article summarizes the factors that may cause AMH changes from 6 aspects such as polycystic ovary syndrome, age, obesity, seasons, ovarian reserve and sexual differentiation abnormalities, and so on to deeply understand the clinical significance and value of AMH changes.