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TIPP is a new pentapeptide isolated from calf thymus and shows immunosuppressive activity.In this study we aimed to investigate the anti-inflammation effect and regulatory mechanism of TIPP.For in vitro study,inhibitory activity of TIPP in degranulation and mRNA levels of cytokines was accessed in IgE-antigen complex stimulated RBL-2H3 cells.For in vivo study,a mouse allergic asthma model was applied.