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5. An affinity-based fluorescence polarization assay for high-throughput screening of prolyl hydroxylas

An affinity-based fluorescence polarization assay for high-throughput screening of prolyl hydroxylas

来源 :2016年长三角药物化学研讨会 | 被引量 : 0次 | 上传用户：wdyyy

【摘 要】

：

Prolyl hydroxylase domain 2 (PHD2) enzyme,a FeⅡ and 2-oxoglutarate (2-OG)dependent oxygenase,which mediate key physiological responses to hypoxia by modulating the levels of hypoxia inducible factor 1

【作 者】

：

Yonghua Lei Qidong You Xiaoj in Zhang 

【机 构】

：

Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicine

【出 处】

：

2016年长三角药物化学研讨会

【发表日期】

：

2016年11期

【关键词】

：

PHD2 FITC-labeled probe affinity-based fluorescence polarization assay 

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　　Prolyl hydroxylase domain 2 (PHD2) enzyme,a FeⅡ and 2-oxoglutarate (2-OG)dependent oxygenase,which mediate key physiological responses to hypoxia by modulating the levels of hypoxia inducible factor 1-α (HIF1α).

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