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Occupant restraint system for frontal passenger is usually designed with male occupant in instead of female occupant,because the Hybrid III 50th male dummy is introduced in China automobile safety regulations.In this study,restraint system simulation model for frontal passenger was established and correlated to vehicle crash test.The protection effects of restraint system for male passenger were compared with those of female passenger.The optimal solution related to seat belt and airbag system was proposed by means of multiple factor variance analysis.Compatibility of occupant restraint system for male and female was also considered in the optimal solution.