【摘 要】
：
Mediator recently has emerged as a central player in the direct transduction of signals from transcription factors to the general transcriptional machinery.
【机 构】
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Department of Cancer and Cell Biology University of Cincinnati College of Medicine USA
【出 处】
：
2011第四届世界癌症大会暨乳腺癌峰会
论文部分内容阅读
Mediator recently has emerged as a central player in the direct transduction of signals from transcription factors to the general transcriptional machinery.Mediator subunit 1 (MED1), through its two classical LxxLL motifs, has been shown to mediate ligand-dependent interactions and functions of nuclear receptors.However, despite the strong in vitro evidence, there currently is no information regarding in vivo functions of the LxxLL motifs either in MED 1 or in other coactivators.
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