【摘 要】
：
Objective: To study the adaptive plasticity of the visual and auditory cortices of early monocular blind macaques using blood oxygenation level dependent function MRI(BOLD-fMRI).Materials and methods:
【出 处】
：
中华放射学学术大会2016、中华医学会第23次全国放射学学术大会暨中华医学会第24次全国影像技术学术大会
论文部分内容阅读
Objective: To study the adaptive plasticity of the visual and auditory cortices of early monocular blind macaques using blood oxygenation level dependent function MRI(BOLD-fMRI).Materials and methods: Four healthy neonatal macaques(postnatal day 7)were randomly divided into 2 groups(group A and group B).The two macaques in group A were kept as a control group.Optic nerve transection was performed in the right eye of the two macaques in group B to establish the monocular blind model.Sixteen and thirty-two months after the operation,each macaque in groups A and B underwent BOLD-fMRI scanning under two auditory stimuli(pure tones and the sounds of birds).The changes in the activation volumes of the bilateral visual,auditory,frontal and parietal cortices between the two groups under the two types of auditory stimuli were compared.The BOLD response changes in both the visual and auditory cortices of monocular blind macaques were further compared using immunofluorescent staining.Results: Under the two types of auditory stimuli,the bilateral visual cortices of the macaques in group B were significantly activated compared with those in group A,and this was particularly obviously in the left visual cortex.These findings were consistent with the immunofluorescence staining finding of an increased number of c-Fos positive cells in the visual cortices of group B.However,the activation volumes of the bilateral auditory cortices in group B decreased,and they decreased more significantly in the left auditory cortex during the two types of auditory stimuli,which was confirmed by the decreased number of c-Fos positive cells in the auditory cortices of group B.In addition,the frontal and parietal cortices of the macaques in group B were also activated under the two types of auditory stimuli.Conclusions: Cross-modal plasticity for the visual and auditory cortices was established in the monocular blind macaques,and it was more obvious in the left visual cortices than the right ones.This finding could be confirmed by immunofluorescent staining.
其他文献
目的：应用磁共振分析单发及复发型视神经炎(optic neuritis,ON)是否存在自发性脑振幅变化及局部脑灰质结构的萎缩,并探讨其相互关系及意义。方法：收集42例单发型ON,35例复发型ON,和50名健康志愿者,获取常规磁共振成像(MRI)、T1加权三维MRI和静息态功能MRI数据及临床信息,探讨这三组样本间低频波动幅度(amplitude of low frequency fluctuati
目的：分析MRI诊断在前置胎盘的产前诊断的应用,并评估其临床价值.方法：选取我院2014年6月至2015年6月我院收治的28例,且术前均接受MRI诊断检查及超声(US)检查,以病理或分娩时临床诊断为金标准,对比分析两种检查的诊断价值.结果：28例前置胎盘和胎盘前置状态孕妇中,其中中央性前置胎盘21例,部分性4例,边缘性3例,在病理诊断或产后发现,MRI正确诊断24例,US正确诊断 22例,两者对前
目的 评价肝动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)联合射频消融(radiofrequency ablation,RFA)治疗中晚期肝癌的疗效.方法 回顾性分析作者采用TACE联合RFA治疗的42例中晚期肝癌患者的临床资料,均在确诊后先行TACE治疗1～4次,根据复查情况联合RFA治疗1～3次.观察并发症的情况、肿瘤大小、甲胎蛋白变
Objective To evaluate the diagnostic performance of three-dimensional arterial spin labeling(3D ASL)MR perfusion imaging technology in intra-axial brain tumors quantitative analysis and imaging charac
目的 应用IVIM技术分析前列腺癌(PCa)、正常外周带(PZ)和良性前列腺增生(BPH)之间的扩散和灌注参数差别.方法 共纳入经超声活检后证实的前列腺癌患者28例,获得16个PCa,22 个PZ,22个BPH,活检前均行MR检查.应用3.0T MRI扫描仪进行成像.检查序列包括轴位、冠状、矢状T2WI,轴位T1WI、IVIM.该IVIM序列采用EPI序列结合并行采集技术,采用11个b值,分别为0
目的 分析高场强磁共振灌注成像技术在胰腺癌中的诊断价值。方法 对33例怀疑胰腺癌的患者依次进行常规MR平扫、MR灌注成像及MR增强扫描,描绘瘤体区、瘤体周边区及正常区的时间-信号曲线(TIC),并分析各区域各项灌注参数的差异性,包括斜率(Slop)、峰值(PE)、达峰时间(TTP)及信号增强率(SR)。结果 胰腺癌瘤体区TIC呈缓慢上升趋势,灌注参数Slop、PE、SR小于瘤体周边区及正常区,而T
目的：研究IgG4相关性肾病(IgG4-related kidney disease)的MRI影像学特征。方法：回顾性分析13例IgG4相关性肾病患者的临床与MRI扫描资料,MRI扫描技术为平扫、扩散加权成像及皮质期、皮髓质期和排泄期三期动态增强扫描,总结患肾外形、信号、增强特点及肾外受累情况。结果：肾脏外形：两肾外形正常者7例,两肾肿大2例,两肾萎缩者2例,肾脏局部凹陷者2例。肾脏信号：T2WI
目的 探讨胎盘植入的影像学表现及介入治疗方法和疗效.资料与方法 本组11例患者，术前作CT平扫、术前术后作超声检查、查血绒毛膜促性腺激素(HCG)，行双侧子宫动脉造影.治疗采用改良式Seldinger技术穿刺插管行盆腔动脉造影，明确出血血管后将5 F Cobra导管超选择插入出血侧子宫动脉，立即用明胶海绵颗粒和明胶海绵条栓塞.栓塞前经导管注入甲氨喋呤(MTX)200 mg.结果 CT发现11例患者
患者,女,28岁,因“胸痛伴咳嗽、活动后气促2+月”入院。入院前2+月患者无明显诱因出现左侧胸部疼痛,并放射至左侧颈部,伴咳嗽、活动后气促,无头晕、头痛,不伴潮热、盗汗,无声音嘶哑等。既往史：2+年前诊断“左侧胸腔积液”,治疗后好转。无高血压、心脏病史,无糖尿病、脑血管疾病病史,无肝炎、结核、疟疾病史,预防接种史不详,无手术、外伤、输血史,无食物、药物过敏史。辅助检查：胸部CT平扫+增强扫描示左侧
目的：研究具有ASiR平台与VHS技术联合应用低剂量MSCT对小儿复杂先天性心血管畸形的诊断正确率,探讨低剂量MSCT对小儿先天性心血管畸形的临床应用价值.资料与方法：回顾性分析我院2012年6月—2015年8月复杂性先天性心血管畸形患儿共 301例,所有患儿均采用ASiR与VHS技术联合应用低剂量扫描方案,并将图像正确诊断率与TTE及金标准(手术结果)进行对照研究.所有原始图像采用GE AM4.