Mammalian sterile 20-like kinase 1/2 inhibit Wnt/□-cateninsignaling pathway by directly binding Case

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：HDGKD30

【摘要】

：

The Hippo signalling pathway can suppress the Wnt/β-catenin signalling pathwayt h r o u g h t h e 1 a s t d o w n s t r e a m e f f e c t o r s Y A P (Y e s-a s s o c i a t e d p r o-tein)/TAZ(tafazzi

【作者】

：

许飞

【机构】

：

复旦大学上海基础医学院

【出处】

：

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

：

2014年3期

【关键词】

：

Hippo signaling pathway Wnt/β-catenin signaling pathway MST1/2 CKlε proteini nte

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　　The Hippo signalling pathway can suppress the Wnt/β-catenin signalling pathwayt h r o u g h t h e 1 a s t d o w n s t r e a m e f f e c t o r s Y A P (Y e s-a s s o c i a t e d p r o-tein)/TAZ(tafazzin).MST(mammalian sterile 20-like kinase)l functions as the upstreamkinase of the Hippo pathway, and CKlε (casein kinase lε) plays roles in the up-stream signaltransduction of the Wnt/β-catenin pathway.

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Mammalian sterile 20-like kinase 1/2 inhibit Wnt/□-cateninsignaling pathway by directly binding Case

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