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  5. Up-regulation of Glioma-associated oncogene homolog 1 expression by serum starvation promotes cell s

Up-regulation of Glioma-associated oncogene homolog 1 expression by serum starvation promotes cell s

来源 :中国病理生理学会第十四届肿瘤专业委员会、第十五届免疫专业委员会联合学术会议 | 被引量 : 0次 | 上传用户：hanqianggege
【摘 要】
：
Tumor microenvironment is characteristic of ischemia and starvation of nutrient.Glil is a strong positive transcriptional activator of the downstream of Hedgehog (Hh) signaling pathway and plays an es
【作 者】
：
Juan Xu Gaoxiang Huang Zongjing Zhang Jieying Zhao Mingzhuo Zhang Yah Wang Zhimin Liu Jian Lu 
【机 构】
：
Department of Endocrinology,Changzheng Hospital,Second Military Medical University,Shanghai,200001,P
【出 处】
：
中国病理生理学会第十四届肿瘤专业委员会、第十五届免疫专业委员会联合学术会议
【发表日期】
：
2014年4期
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　　Tumor microenvironment is characteristic of ischemia and starvation of nutrient.Glil is a strong positive transcriptional activator of the downstream of Hedgehog (Hh) signaling pathway and plays an essential role in the development of cancers,including breast cancer.The main purpose of this study was to investigate thepro-survival effect of Glil under serum starvation and its molecular mechanism in ER-positive breast cancer MCF-7 and T47D cells.The resuhs revealed that serumstarvation significantly up-regulated the expression of Glil by activated PI3K/AKT pathway.
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