Objective: The chemokines in tumor microenvironment play important roles in tumor growth and progression. C-C chemokine (C-C motif) ligand 18 (CCL18) has been previously reported to be capable of inducing tumor cells invasion and metastasis via binding to the receptor PITPNM3 in breast cancer cells. This study aimed to investigate the expression and significance of PITPNM3 in hepatocellular carcinoma (HCC).