【摘 要】
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Objective: EGFR-T790M mutation, which is the valuable target for next generation of EGFR-TKI, accounts for about half of acquired resistance to current EGFR-TKI therapy in EGFR sensitive mutation posi
【机 构】
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200433 Shanghai Pulmonary Hospital, Tongji University Medical School, Shanghai, China
【出 处】
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第十七届全国临床肿瘤学大会暨2014年CSCO学术年会
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Objective: EGFR-T790M mutation, which is the valuable target for next generation of EGFR-TKI, accounts for about half of acquired resistance to current EGFR-TKI therapy in EGFR sensitive mutation positive NSCLC patients.Due to clinical challenge in obtaining tumor re-biopsies, noninvasive detection of EGFR-T790M in plasma circulating free DNA (cfDNA) has been proved to be valuable and feasible.
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