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Cyclometallated complexes have attracted considerable interest due to their application in medicine and bioimaging.1 Recently,we reported on synthesis and interaction with bovine serum albumin of cyclometallated Pd(Ⅱ)complexes A-H(Figure 1)containing arylimine and salicylaldimine co-ligands.2 Following this study,here we describe the antibacterial activity and DNA interaction of complexes A-H.