【摘 要】
：
Myocardial ischemia causes rapid depletion of ATP in part due to inefficient hydrolysis of ATP when the mitochondrial F1F0 ATP synthase switches to a hydrol
【机 构】
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Robert Wood Johnson Medical School USA
【出 处】
：
BITs 1rd Annual World Cancer Congress of Cardiology-2009(200
论文部分内容阅读
Myocardial ischemia causes rapid depletion of ATP in part due to inefficient hydrolysis of ATP when the mitochondrial F1F0 ATP synthase switches to a hydrolase, which serves no useful work.The amount ofATP hydrolyzed by this enzyme during myocardial ischemia represents a substantial fraction of that used during an ischemic event.Studies with oligomycin (inhibits both F1F0 ATP synthase and hydrolase activities) done previously showed that it conserved ATP during ischemia and its efficacy varied with species.A peptide, IF-1, activated by low pH and conditions similar to those seen during ischemia, inhibits F1F0 ATP hydrolase activity and is highly expressed in "slow heart rate species" (dog, rabbit) and poorly expressed in rat.
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