【摘 要】
：
Ohjective To determine the microRNA (miRNA) expression profiles during the differentiation of human embryonic stem(hES) cells into insulin producing cells (IPCs), and to detect the roles and mechanism
【机 构】
：
Department of Endocrinology and Metabolism,Peking University Third Hospital
【出 处】
：
中华医学会第十二次全国内分泌学学术会议
论文部分内容阅读
Ohjective To determine the microRNA (miRNA) expression profiles during the differentiation of human embryonic stem(hES) cells into insulin producing cells (IPCs), and to detect the roles and mechanism of specified miRNAs during the process.Methods 1.The hES cells were differentiated into IPCs.The miRNA expression profiles of stage Ⅳ and Ⅴ cells and human adult islets were detected by high-throughput sequencing.2.
其他文献
Objective Previous studies have proved that GLP-1 had cardiovascular protective effects by directly acting on cardiovascular system or by improving metabolism, which are both believed to be mediated a
Deficiency of beta-cell mass and failure of islet function are major characteristics in both type 1 and type 2 diabetes.Therefore, endogenous beta-cell mass restoration and islet function reconstructi
Objective AGEs is one of the pathogenic factors of DN,and our previous work has suggested that AGEs may play a central role in the pathogenesis of glomeruloselerosis.The aim of this study is to furthe
Background and Objective The aim of this study is to test the hypothesis that elevated levels of serum leptin and interleukin-6 (IL-6) during the first postpartum year may be related to the occurrence
背景:西方国家绝大多数原发性甲旁亢为无症状的患者.甲状旁腺癌的发病率低于1％,但最近有上升趋势.近10年中国原发性甲旁亢的临床表现的变化仍不清楚.方法:本研究分析了2000年至2010年在上海瑞金医院就诊的249名原发性甲旁亢患者的临床资料.
Graves disease (GD), with recent data showing a prevalence of hyperthyroidism up to 1.3％ (0.5％ clinical and 0.7％subclinical) in the U.S.and 0.25～1.09％ in China, is one of the most common autoimmune di
Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism.FGF23 is predominately produced by osteocytes/osteoblasts and exerts its bio
Objective To evaluate the effect of Motivational Interviewing on the quality of life and correlation factor(Blood Glucose,Lipid parameters, self-care behavior) in type 2 diabetes with bad blood glucos
Results Proportion of Subclinical hypothyroidism, overt clinical hypothyroidism, subclinical hyperthyroidism, overt hyperthyroidism, hypothyroxinemia were 13.39％, 0.66％, 1.32％,1.16％ and 0.17％ respecti
Objective It is widely considered that hyperinsulinemiceuglycemic clamp is the "gold standard" method for assessing insulin sensitivity in vivo.We sought to assess whether GLP-1analogue liraglutide im