【摘 要】
:
It is no doubt that methylation plays an important role in breast cancer development and progression.Aberrant promoter CpG island hypermethylation is associated with transcriptional silencing.Tumor su
【机 构】
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Molecular Pathology Laboratory Shanghai Ob/Gyn Hospital of Fudan University China
【出 处】
:
(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C
论文部分内容阅读
It is no doubt that methylation plays an important role in breast cancer development and progression.Aberrant promoter CpG island hypermethylation is associated with transcriptional silencing.Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may lead to malignancy by deregulation of cell and growth cycles.We used a pyrosequencing methylation analysis to study the methylation of 12 known growth-suppressor genes (ARHI,RASSF1A, HIN-1, RARβ2, hMLH1, 14-3-3σ, RIZ1, p16, E-cadherin, RIL, CDH13, and NKD2) in 90 pairs of malignant/normal breast tissues.Five of them (RIL, HIN-1, RASSF1A, CDH13, and RARβ2) were frequently methylated in breast cancers, but not the normal breast.Two panels of methylation profiles were defined.The methylation of the HIN-1/RASSFIA panel strongly correlated to the expression of ERs, PRs, and hormone receptors.
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