Hypermethylation of Tumor Suppressor Genes is Correlated to Hormone Receptor Status in Breast Cancer

来源 :(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C | 被引量 : 0次 | 上传用户:qaz1164
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  It is no doubt that methylation plays an important role in breast cancer development and progression.Aberrant promoter CpG island hypermethylation is associated with transcriptional silencing.Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may lead to malignancy by deregulation of cell and growth cycles.We used a pyrosequencing methylation analysis to study the methylation of 12 known growth-suppressor genes (ARHI,RASSF1A, HIN-1, RARβ2, hMLH1, 14-3-3σ, RIZ1, p16, E-cadherin, RIL, CDH13, and NKD2) in 90 pairs of malignant/normal breast tissues.Five of them (RIL, HIN-1, RASSF1A, CDH13, and RARβ2) were frequently methylated in breast cancers, but not the normal breast.Two panels of methylation profiles were defined.The methylation of the HIN-1/RASSFIA panel strongly correlated to the expression of ERs, PRs, and hormone receptors.
其他文献
To sort out patients with serious or even life-threatening diseases from the vast majority of chest pain patients with trivial diseases is a very important task for emergency physicians.Accurate labor
会议
Coronary vasospasm (CVsp) plays an important role in the pathogenesis not only of variant angina but also of ischemic heart disease, including effort angina, unstable angina, acute myocardial infarcti
会议
Fast track programs have been introduced to improve postoperative outcome(1), also in vascular surgery(2).It deals with programs that have the purpose of optimizing whole perioperative care(3).We have
会议
Self-management is vital to maintaining heart failure (HF) patients health.Globally, health systems face significant barriers that limit their ability to provide ongoing health monitoring and behavior
会议
Previous studies indicate a mixed lineage kinase, called leucine-zipper and sterile-alpha motif kinase (ZAK) could induce apoptosis through p-JNK activation, and northern blot analysis also reveal tha
会议
Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are the two assays currently used to determine HER2 status in routine practice.Identification of HER2 status is a prerequisite
会议
Phosphorylated HER2 (pHER2) may more accurately reflect the signaling and functional activity of the HER2 protein than detection of HER2 itself.The detection of HER2 gene amplification using fluoresce
会议
Genetic interactions that modify cancer risk estimates can provide insight into fundamental mechanisms of carcinogenesis.Combined with complementary strategies, a systems-level investigation of gene e
会议
Differentiation of monolayered epithelia is characterized by the formation of a basoapical polarity axis.In ducts and glands, apical polarity results from the positioning of tight junctions at the ape
会议
Background: Since the identification ofBRCA germline mutation, there have been no major breast cancer susceptibility genes that discovered by linkage analysis.Based on set of criteria including early
会议