【摘 要】
：
Background: Major depressive disorder is often associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis by chronic stress.In comparison, psychosocial stress-induced activation of
【机 构】
：
Oita University Faculty of Medicine, Japan
【出 处】
：
国际预防自杀协会(IASP)第26届世界大会
论文部分内容阅读
Background: Major depressive disorder is often associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis by chronic stress.In comparison, psychosocial stress-induced activation of salivary α-amylase (sAA) functions as a marker of sympathoadrenal medullary system (SAM) activity.However, in contrast to salivary cortisol, sAA has been less extensively studied in major depressive disorder patients.The present study relationship between suicidal idea and sAA and salivary cortisol levels in patients with major depressive disorder.Methods: The authors determined Profile of Mood State (POMS) and State-Trait anxiety Inventory (STAI) scores, Heart Rate Variability (HRV), and sAA and salivary cortisol levels in 19 patients with major depressive disorder with suicidal idea and 20 patients without suicidal idea following the application of electrical stimulation stress.Patients with major depressive disorder were 8 points or more on Hamilton Depression Scale (HAM-D) scores.Results: Trait and state anxiety in patients with major depressive disorder with suicidal idea were significantly increased compared to patients without suicidal idea.Tension-Anxiety, Depression-Dejection, and Fatigue scores in patients with major depressive disorder with suicidal idea were significantly increased compared to patients without suicidal idea.There was no difference in heart rate variability measures between major depressive disorder patients and healthy controls.Finally, there were no differences in salivary amylase and cortisol levels between both groups.Conclusion: These preliminary results suggest that anxiety might be an important factor for suicidal idea in major depressive disorder.
其他文献
Background: From 1997 to 2009, there were 1050 aged 15-24 adolescents committed suicide in Hong Kong, the suicide rates among these 14 years were between 5.9 per 100,000 (1999 the lowest) and 12.5 per
Background: In China the mean annual suicide rate is 23 per 100,000 and there are about 287,000 suicide deaths per year.Suicide, an important public health problem, seriously affects social and econom
Many countries have identified rural suicide as a major public health concern, yet suicide research on epidemiology, service utilization and prevention tends to focus on urban areas, resulting in a co
Background: Both MMPI-A and MMPI-2 are most widely used psychological assessment tools in Korea.In this study, their clinical usage in assessing suicide risk was discussed.Methods: 380 high school stu
Objective: Faced with high prevalence of psychiatric illnesses, increasing socio-economic inequality, and high suicide rates, Chinas rural physicians (previously known as the "barefoot doctors") are i
Background: Finnish Association for Mental Health arranges courses and groups for bereaved by suicide or other kind of traumatic event.Association ordered an evaluation research from Innokuntoutus in
In Uruguay, a heart-shaped country in Latin America, the community is the first source of prevention.From 2004 till now, four plans have been developed to prevent suicide behaviour in different parts
This paper discusses the experience of the Samaritans in the development of a suicide prevention programme for adolescents-the Young Samaritans Peer Support Programme (YSPSP).The organization has 9 ye
Objective: To explore the association of body mass index and perceived weight with suicide ideation and mood among female college students.Methods: All of the students in their first grade from nine d
Objective: Suicide is the leading cause of mortality in Japanese university students.This is the first study to evaluate prevalence and correlates of suicidal ideation, suicide behaviour, and exposure