Residue-level elucidation of pore curvature effects on protein structural change during chromatograp

来源 :The 7th Sino-US Conference of Chemical Engineering(第7届中美化学工程 | 被引量 : 0次 | 上传用户：augenthaler

【摘要】

：

【作者】

：

Dongxia Hao Guanghui Ma

【机构】

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National Key Lab of Biochemical Engineering, Institute of Process Engineering,Chinese Academy of Sci

【出处】

：

The 7th Sino-US Conference of Chemical Engineering(第7届中美化学工程

【发表日期】

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2013年11期

【关键词】

：

protein chromatography pore size or curvature NMR hydrogen and deuterium(h/d)exc

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　　Elucidation of protein microscopic behavior in porous media is an important determinant to design and optimize the purification and separation of protein by chromatography.To date,accurate residue details about pore size(curvature)of porous media on proteins binding and unfolding during chromatography were still unknown.

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