【摘 要】
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Background and purpose: Fatty acid translocase CD36 (FAT/CD36) is a transmembrane glycoprotein that mediates long-chain fatty acid (LCFA) uptake/intracellular transport and also functions as a scaveng
【机 构】
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Key Laboratory of Metabolism of Lipid and Glucose, Centre for Lipid Research, Chongqing Medical Univ
【出 处】
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2014年第十二届全国脂质与脂蛋白学术会议
论文部分内容阅读
Background and purpose: Fatty acid translocase CD36 (FAT/CD36) is a transmembrane glycoprotein that mediates long-chain fatty acid (LCFA) uptake/intracellular transport and also functions as a scavenger receptor.While a closely association between CD36 and the pathogenesis of NAFLD is well-defined, little is known about the role played by the post-translational palmitoylation of CD36 in lipid accumulation or inflammation in hepatic cells.Experimental approach: The palmitoylation sites of human FAT/CD36∶ cys4, cys7, cys464, cys466, were substituted by alanines or serine using mutation approach.
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