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The activity,localization and fate of a vast number of cellular proteins are regulated through ubiquitination,a process whereby one or more ubiquitin (Ub) monomers or chains are covalently attached to target proteins.Of particular interest in signaling is the ability of the Ub modification to induce de novo protein: protein interactions,through the recognition of ubiquitinated proteins by proteins harboring Ub-binding domains ( UBDs),a mechanism that sits at the heart of several signaling cascade.