Identification of Nitric Oxide-Releasing Derivatives of Oleanolic Acid as Potential Anti-Colon Cance

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：zx19910412

【摘要】

：

【作者】

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Yu ZOU Junjie FU Zhangjian HUANG Huibin ZHANG and Yihua ZHANG

【机构】

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Center of Drug Discovery,China Pharmaceutical University,Nanjing 210009

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

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2015年3期

【关键词】

：

Anti-Colonic Cancer Nitric Oxide donor oleanolic acid Wnt/β-catenin pathway

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　　The overexpressed GSTπ isozyme in tumor cells was regarded as targets for the design of anti-cancer agents.Herein,a group of GSTπ-based nitric oxide(NO)-releasing derivatives of oleanolic acid(OA)(1–9)were designed,synthesized and biologically evaluated for their anti-colon cancer activity.

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Identification of Nitric Oxide-Releasing Derivatives of Oleanolic Acid as Potential Anti-Colon Cance

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