【摘 要】
:
In the past ten years, several publications have highlighted the role of the regulator of G protein signalling (RGS) family in multiple diseases.As one of the multifunctional family members, RGS14 is
【机 构】
:
Center of Clinical Pharmacology,the Third Xiangya Hospital,Central South University,Changsha,Hunan P
【出 处】
:
Ready for 2018- the 4th China International Forum on Hyperte
论文部分内容阅读
In the past ten years, several publications have highlighted the role of the regulator of G protein signalling (RGS) family in multiple diseases.As one of the multifunctional family members, RGS14 is involved in various biological processes, including synaptic plasticity, cell division and phagocytosis.However, the role of RGS14 in pathological cardiac remodelling remains unclear.in the present study, we used a genetic approach to examine the role of RGS14 in pathological cardiac hypertrophy both in vivo and in vitro.We observed that RGS14 was downregulated in human failing hearts, murine hypertrophic hearts and isolated hypertrophic cardiomyocytes.Moreover, the extent of aortic banding-induced cardiac hypertrophy, dysfunction and fibrosis were exacerbated in RGS14 knockout mice, whereas RGS14 transgenic mice exhibited a significantly alleviated response to pressure overload.Mechanism research revealed that the RGS14-dependent rescue of cardiac remodelling was associated with the abrogation of mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated protein kinase (ERK) 1/2 signalling.Furthermore, constitutive activation of MEK1 nullified the cardiac protection in RGS14 transgenic mice.Conversely, inhibition of MEK-ERK1/2 by U0126 reversed RGS14 deletion-related hypertrophic aggravation.These results demonstrate that RGS14 attenuates the development of cardiac remodelling through the MEK-ERK1/2 signalling and RGS14 may be a promising target for the treatment of pathological cardiac remodelling.
其他文献
Objective:Epidemiological and experimental studies suggest that maternal diabetes programs adult hypertension in the offspring, but the underlying mechanisms are incompletely understood.Here, we test
Objective:Essential hypertension (HTN) is the most common cardiovascular disease that can lead to the left ventricular hypertrophy (LVH).QT prolongation is an independent risk factor for sudden cardia
Objective:To investigate the impacts of amlodipine, valsartan and their combination on blood pressure variability and pulse wave velocity and to provide reference for clinical medication.Methods:We co
Exercise is a major nonpharmacological treatment for hypertention, but its underlying mechanisms are still not completely elucidated yet.Irisin, a polypeptide containing 112 amino acids, is mainly sec
Objective:Nebivolol, a third-generation β-adrenergic receptor (β-AR) blocker, has potential cardiac protective effects in obese individuals; however, the underlying mechanism remains unclear.In this s
Objective:Inflammation has been proposed to influence multiple aspects of cholesterol metabolism.Prostaglandin E2 (PGE2) is an important lipid mediator in inflammation.However, whether or how PGE2 reg
Objective:To evaluate the left atrial phasic function of hypertensive patients with or without coexisting diabetes using two-dimensional speckle tracking echocardiography (2DSTE)-based strain and stra
Objective:To explore the relationship between the long-term arterial stiffness and plasma high-sensitivity C reactive protein (hsCRP) levels in young adults.Methods:This cohort study comprised 231 you
Background and Objective:Clinical practice guidelines (CPGs) provide explicit recommendations for clinical practice in order to optimize results, minimize risks and promote cost-effective practice.The
Adverse environment in early life can modulate the adult phenotype, including blood pressure.Lipopolysaccharide (LPS) exposure in utero results in increased blood pressure in the offspring, but the ex