Dietary restriction (DR) is the most powerful natural means to extend lifespan.Although several genes can mediate responses to alternate DR regimens,no single genetic intervention has recapitulated the full effects of DR,and no unified system is known for different DR regimens.Here we obtain temporally resolved transcriptomes during chronic DR and intermittent fasting (IF) in Caenorhabditis elegans,and find that early and late responses involve metabolisms,and cell cycle/DNA damage,respectively.We uncover three network modules of regulators by target specificity.By genetic manipulations of nodes representing discrete modules,we induce transcriptomes that progressively resemble DR as multiple nodes are perturbed.Targeting all three nodes simultaneously results in extremely long-lived animals that that are refractory to DR.These results and dynamic simulations demonstrate that extensive feedback controls among regulators may be leveraged to drive the regulatory circuitry to a younger steady state,recapitulating the full effect of DR.