Background, Motivation and Objective Intra- and extra- muscular hematomas result from repetitive injury as well as sharp and blunt limb trauma. The clinical consequences can be serious including debilitating pain, functional deficit and limb threatening extremity compartment syndrome. Due to gelatinous nature, hematomas can only be drained surgically, which can be disfiguring and is associated with significant morbidity. The goal of this work was to evaluate the feasibility of HIFU-based technique termed histotripsy for rapid (within clinically relevant timeframe of 15-20 minutes) liquefaction of large volume (up to 30 ccs) extra-vascular hematomas for subsequent fine-needle aspiration. Two different histotripsy methods have been developed, cavitation histotripsy (CH) and boiling histotripsy (BH). Both methods utilize very short (microsecond-millisecond) HIFU pulses at a low duty factor. Each pulse induces violent bubble activity at the focus, which leads to tissue lysis into subcellular debris without broad thermal effects. The induced bubbles are highly echogenic and allow for precise targeting and treatment monitoring.