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Obesity has become a global public health problem associated with complications including type 2 diabetes, cardiovascular disease and several cancers.Adipocyte differentiation (adipogenesis) plays an important role in obesity and energy homeostasis.Adipose tissue secretes mnultiple cytokines and adipokines which can cause the complications of obesity, especially insulin resistance.TNF-α, IL-6, leptin and resistin have been identified as the main regulators of obesity and insulin activity.