基于β糖基转移酶检测RNA中hm5C方法的研究

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：yaohaochang

【摘要】

：

DNA中的5-甲基胞嘧啶是最具特征的表观遗传修饰，且在各种细胞过程中起着至关重要的作用.TET蛋白可以将5-甲基胞嘧啶(5mC)特异性氧化成为5-羟甲基胞嘧啶(5hmC)，这种现象在RNA中也同样被发现.[1]RNA中hm5C可能通过调控RNA和蛋白质相互作用来调节基因的表达.[2]为了更加清晰的揭示hm5C的生物学功能，我们需要寻找更多新的检测方法.

【作者】

：

袁羽书翁小成周翔

【机构】

：

生物医用高分子教育部重点实验室,武汉大学化学与分子科学学院,武汉,430072

【出处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

表观遗传修饰 TET 5-羟甲基胞嘧啶 β糖基转移酶

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基于β糖基转移酶检测RNA中hm5C方法的研究

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