【摘 要】
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Baekgrounds Glypican-3 (GPC-3) has been reported as one of the most promising serum markers for hepatocellular carcinoma (HCC), while several studies have conflicting Conclusions for the diagnostic ac
【机 构】
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Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical University, Chongqi
【出 处】
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中华医学会第十六次全国病毒性肝炎及肝病学术会议
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Baekgrounds Glypican-3 (GPC-3) has been reported as one of the most promising serum markers for hepatocellular carcinoma (HCC), while several studies have conflicting Conclusions for the diagnostic accuracy between GPC-3 and alpha-fetoprotein (AFP).Methods Studies that explored the diagnostic value of GPC-3 and AFP in HCC were searched in MEDLINE, EMBASE, PUBMED, the Cochrane Library and Chinese BioMedical Literature Database (CBM).Sensitivity, specificity and other measures about the accuracy of serum GPC-3 and AFP in the diagnosis of HCC were pooled using random-effects models.Summary receiver operating characteristic curve (sROC) analysis was used to summarize the overall test performance.Results Ten studies were included in our meta-analysis.The pooled sensitivity for AFP and GPC-3 are: AFP 51.9％ (95％ confidence interval (CI) : 0.47-0.56), GPC-3 59.2％ (95％ CI: 0.55-0.63) ; while the pooled specificity for AFP and GPC-3 are: AFP 94％ (95％CI: 92.1％ to 95.6％), GPC-3 84.8％ (95％CI: 82％ to 87.3％).The pooled diagnostic odds ratio (DOR): AFP 23.4 (95％CI: 10.3-53.2), GPC-3 17.99 (95％CI: 5.4-60.4).Area under sROC for AFP and GPC-3 are the same as 0.81 (95％ CI: 0.77-0.84)Conclusions GPC-3 is comparable to AFP as a serum marker for the diagnosis of HCC, combination of AFP and GPC-3 can elevate the sensitivity of diagnosis.
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