Clinical restenosis following coronary artery angioplasty (PTCA) occurs in up to 30% of the patients within 6 months of treatment.Endothelial dysfunction in diseased and/or mechanically injured arteries may be a key factor in the process.Enhanced External Counterpulsation (EECP) is an effective noninvasive treatment for coronary artery disease (CAD),which has recently been shown to augment nitric oxide (NO) production.Thus,we postulate that EECP would reduce the restenosis rates after PTCA through its effects on endothelial function.24 patients (pts) one-month post successful PTCA were randomized to EECP (15 pts) or Control (9 pts).At 6 month follow-up MACE and recurrence of ischemia in the PTCA related regions demonstrated by scintigraphy were observed in 13% of the EECP treated group and in 44% of the Control group (p<0.01).This pilot study suggests that further investigation of EECP in reducing restenosis is warranted.