A semi-mechanistic population pharmacokinetic model describing the time-dependent kinetics of Red Bl

来源 :第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu | 被引量 : 0次 | 上传用户:jiebaidexue
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Background: XQ (Carfree, Nanjing, China), a new chemical entity that possesses pharmacological activity on PlateletActivating Factor (PAF).XQ was approved into phase Ⅰ evaluation for treatment of ischemic stroke in China.A nonlinear red blood cell (RBC,) binding/partition was observed in clinical trial within PUMCH, however in vitro assay result indicates that the blood to plasma (B/P) ratio of XQ is concentration time independent.
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