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目的:探讨甘石冰脑洗剂的抗炎、止痒作用。方法:实验一在大鼠的左后足背剪毛部位湿敷生理盐水、炉甘石洗剂、甘石冰脑洗剂,连续3天后,每只大鼠左后足跖皮下注射10%鸡蛋清液,分别测定致炎前后足跖厚度,计算肿胀率结果进行数据分析。实验二在大鼠的右后足背剪毛部位湿敷生理盐水、炉甘石洗剂、甘石冰脑洗剂1h后,在各右后足滴0.01%的磷酸组织胺50μL/爪,以后每隔3min在同部位再滴浓度递增的磷酸组胺,直至大鼠出现舔足为止,以此段时间内给各动物所滴的磷酸组胺的总量为致痒阈,并将每组内各动物的致痒阈进行统计学分析。结果:甘石冰脑洗剂对10%鸡蛋清液大鼠足跖肿胀率具有显著抑制作用,与炉甘石洗剂比较P<0.05;甘石冰脑洗剂能显著提高磷酸组胺致大鼠足痒的致痒阈,与炉甘石洗剂比较P<0.05。结论:甘石冰脑洗剂具有抗炎、止痒的作用。
Objective: To investigate the anti-inflammatory and anti-itch effects of Ganshi Bingnao lotion. METHODS: During the first experiment, saline, calamine lotion, and Ganshichuangnao lotion were wetly applied to the left back of the rat’s back hairs. After 3 consecutive days, each rat was injected subcutaneously with 10% egg white. The thickness of the athlete’s foot was measured before and after inflammation, and the swelling rate was calculated and analyzed. In the second experiment, wet saline, calamine lotion, and Ganshi Binaural lotion were applied to the right hind paws of rats after 1h, and 0.01% of histamine phosphate 50 μL/claw was placed on each right hind paw, and every 3 minutes thereafter. Phosphate histamine was added dropwise at the same site until the rat developed lameness. The total amount of histamine phosphate dropped to each animal during this period was the threshold for itching, and each animal within each group was The itch threshold was statistically analyzed. Results: Ganshi Bingnao lotion had a significant inhibitory effect on paw swelling rate in rats with 10% egg serum. Compared with calamine lotion, P<0.05; Ganshi Bingnao lotion could significantly increase histamine-induced paw itch in rats. Throat threshold, compared with calamine lotion P<0.05. Conclusion: Ganshi Bingnao lotion has anti-inflammatory and antipruritic effects.