Curcumin (Cur) is widely known for its medicinal properties including anticancer efficacy.However,one of the serious drawbacks of curcumin is its poor aqueous solubility and instability which lead to reduced systemic bioavailability.With a view to address these issues,we designed a simple method for the fabrication of water soluble Cur conjugated selemium nanoparticles (SeNPs) to target various cancer cell lines.