【摘 要】
：
We here disclosed a facile method to realize the dihydroxylation of alkenes[1] with the assistance of amide The proposed 5-Exo-Trig cyclization was verified by alternative synthesis of 3-subsituted-5-
【机 构】
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CAS Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemis
【出 处】
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The 24th International Society of Heterocyclic Chemistry Con
论文部分内容阅读
We here disclosed a facile method to realize the dihydroxylation of alkenes[1] with the assistance of amide The proposed 5-Exo-Trig cyclization was verified by alternative synthesis of 3-subsituted-5-hydroxymethyl-γ-lactones.By switching the solvent, hydroxyalkyl lactams were obtained by diastereospecific oxamidation under the reaction conditions developed by Wardrop[2].A SN2-1ike ring-opening of aziridinium ion is discussed and N-aryl nitrenium ion[3] may not be possibly involved in the oxamidation process.
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