Dihydroxylation/Oxamidation of the Alkenes Promoted by Phenyliodine(Ⅲ) bis(trifluoroacetate) (PIFA)

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户:woxuejavalala
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We here disclosed a facile method to realize the dihydroxylation of alkenes[1] with the assistance of amide The proposed 5-Exo-Trig cyclization was verified by alternative synthesis of 3-subsituted-5-hydroxymethyl-γ-lactones.By switching the solvent, hydroxyalkyl lactams were obtained by diastereospecific oxamidation under the reaction conditions developed by Wardrop[2].A SN2-1ike ring-opening of aziridinium ion is discussed and N-aryl nitrenium ion[3] may not be possibly involved in the oxamidation process.
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