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In order to explore the role of curcumin for oxygen Glucose deprivation in neuron cells, the experiments have been carried out by using cultured hippcampal HT22 cells.The design is divided into eight groups:l) normal controls;(2) simple OGD;(3) OGD + 0.05% DMSO;(4) OGD + 0.05% DMSO + Curcumin 5μM;(5) OGD + 0.10% DMSO (6)OGD+ 0.10% DMSO + Curcuminl0μM;(7) OGD + 0.20% DMSO;(8) OGD + 0.20% DMSO + Curcumin 20μM.