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Chemical enhancers are widely used for facilitating drug penetration in transdermal drug delivery system(TDDS).However,there is a lack of knowledge about how the enhancement effect changes over time.In this study,on the basis of kinetic parameters of enhancement effect,molecular details of the dynamic enhancement process was described and a new hypothesis of the recovery mechanism of the skin barrier functionwas proposed.The effects of Azone(AZ)and menthol decanoate(MT-10)were evaluated with in vitropermeationexperiment,confocal laser scanning microscopy(CLSM)and TEWL.