Retinoid-related orphan receptor gamma-t(RORγt)belongs to the nuclear receptor superfamily that takes vital roles in the development and maturation of T-helper 17 cell(Th17)and lymph-node genesis.Because Th17 cells have been proved to be major effectors in human autoimmune and inflammatory diseases,the agonists and antagonists of RORγt have been discovered as promising leads for the therapeutics of these diseases1-4.