论文部分内容阅读
目的 To investigate the role of epithelial-mesenchymal transition (EMT) in airway inflammation and airway remodeling as well as the possible therapeutic mechanism of BCG for the treatment of asthma.方法 Wistar rats were sensitized and challenged by ovalbumin for 2 weeks or 8 weeks.BCG was subcutaneously administered daily before every ovalbumin challenge or intracutaneously vaccinated on days 1,3,and 7 before sensitization to determine its therapeutic effects.Airway inflammation and airway remodeling changes were observed by HE stain under the light microscopy.The thicknesses of airway wall (WAt) and airway smooth muscle (WAm) were determined by morphometric analysis.