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Purpose: To evaluate the biomechanical properties of the cornea CorVis ST(CST),basal epithelial cell density(BEC)and sub-basal nerve plexus(SBN)in vivo confocal microscopy(IVCM)in patients with diabetes mellitus(DM)and normal control subjects.Methods: A comparative cross-sectional study that included 30 patients with DM(DM group)and 30 normal control subjects matched for intraocular pressure(IOP)and central corneal thickness(CCT)(Normal group).The BEC and SBN were obtained with the IVCM and analyzed with image J.The CCT,IOP and Corneal biomechanical properties were measured with CorVis ST.