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Systems biology aims to understand the behavior of a biological system at the system level by means of investigating the behavior and interactions of all the components in the system.Due to the ability to produce data of one and the same phenomenon at different scales,the modeling of biological systems is moving from single scales to multiple scales,e.g.,from the molecular scale to the cell,tissue,and even the whole organism level.In this report,we will present a colored Petri net approach to modeling and analyzing multiscale systems biology.Specifically,in this report you will see what are colored Petri nets,what challenges of multiscale systems biology can be tackled by colored Petri nets,a colored Petri net framework for multiscale systems biology,and a couple of case studies.