PtxM (M= Ni,Co) alloy nanoparticles (NPs) have been successfully fabricated by the chemical reduction method,using carbon (Vulcan XC-72) as support.It is found that the NPs are well-dispersed on the carbon surface,with particle size of about 10 nm,and exhibit many unique features.Under physiological conditions,the oxidation current of glucose is linear with concentration from 2 μM to 8.5 mM,with high sensitivity of 1795.1 μA·m M-1·cm-2.In addition,interference from the oxidation of ascorbic acid,uric acid,or acetamidophenol could be effectively avoided.The non-enzymatic glucose sensors based on this electrode exhibited excellent selectivity,stability,and repeatability.Thus,this novel non-enzyme sensor has potential application in glucose detection.