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  5. Tacrolimus Inhibit Vascular Contraction via Activation of BKca Currents by Increasing Ca2+ Sparks Re

Tacrolimus Inhibit Vascular Contraction via Activation of BKca Currents by Increasing Ca2+ Sparks Re

来源 :The 6th China-Russia International Conference on Medicine(第六 | 被引量 : 0次 | 上传用户：sdniloveu
【摘 要】
：
Aim: The vasoactive properties of tacrolimus were inconsistent.There was report that tacrolimus could activate spontaneous transient outward currents (STOCs) by activation of the large conductance Ca2
【作 者】
：
Yu-fang Chen Rui Zhang Yi-Wu Li Ji-Zhou Xiang Qiang Tang 
【机 构】
：
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, W
【出 处】
：
The 6th China-Russia International Conference on Medicine(第六
【发表日期】
：
2014年3期
【关键词】
：
Ca2+spark aorta smooth muscle cell BKCa tacrolimus whole-cell patch technique 
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Aim: The vasoactive properties of tacrolimus were inconsistent.There was report that tacrolimus could activate spontaneous transient outward currents (STOCs) by activation of the large conductance Ca2+-activated K+ channels (BKCa) channels in bladder smooth muscle cells by augmenting elementary Ca2+ release events (Ca2+ sparks) leading to transient membrane hyperpolarization.
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