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Aims:To determine incidence and clinically relevant risk factors for diabetic amputation in a large cohort study of diabetic foot ulceration patients in China.Methods: To investigate total 669 diabetic foot ulceration patients,who were assessed at baseline for demographic information,medical and social history,peripheral neuropathy screening,periphery artery disease screening,assessment of nutritional status and diabetic control,physical examination including foot deformity in fifteen Grade Ⅲ-A hospitals.Results: Of the 669 patients,435 were male and 201 were female,with mean age being 64.0 years.Of all patients,110 were neuropathic ulcers,122 were ischemic ulcers,276 were neuroischemic ulcers,12 were unclassified.Wagner classification showed 61 cases were grade Ⅰ,216 cases grade Ⅱ,159 cases grade Ⅲ,137 cases grade Ⅳ,7 case gradeⅤ.