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Functionalization of nanostructures with different biological molecules has many applications in pharmaceutical science for efficient drug delivery, biomedical imaging, clinical diagnosis and therapy.In the recent years, Gold Nanoparticles (AuNPs) based nanocarriers have emerged as attractive candidates for delivery of various payloads into their targets.Researchers, until date, mostly employed AuNPs larger than 10 nm in size for different biological and medicinal applications.