Obesity is a growing global public health dilemma.The combination of diet and exercise is not sufficient for many patients to maintain a weight loss.Antiobesity medicines have limited efficacy and bariatric surgery is available only to the very obese.Resistant starch (RS) is a functional food that reduces body fat in rodents and humans.Satiety hormones peptide YY and glucagon-like peptide-1 acting centrally and/or locally decrease energy intake via neuronal and/or hormonal signaling, and butyrate upregulates the gene expression of these gastrointestinal hormones and neurotransmitters.