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Introduction Substance addition is a challenging social and public health problem inthe world．Cocaine dependent individuals show deficits in brain structure，function and metabolism．Voxel—based morphometry(VBM)studies have reported gray matter(GM)density／volume decreases in thefrontal and temporal cortices in cocaine users(CU)．However,whether these GM deficits affect brainfunctional networks is unknown．Resting-state functional connectivity(rsFC)techniques now make itpossible to address this question．In this study,we test the hypothesis that structural changes in brain GMaffect functional connectivity of brain networks related to these structures．Specifically,brain regions with aGM volume decrease in CU were identified using VBM，and these regions were then used as seeds in afunctional connectivity analysis tO examine the integrity of brain networks associated with these structuredeficits．Methods Participants：Thirty-nine active CU and 39 healthy controls(HC)matched on gender(10 VS 16 females)，age(40．0±5．1 VS 38．0±6．2 years)，race(34 African American，3 Caucasian and 2mixed-race CU VS 28 African American，9 Caucasian，1 Hispanic and 1 Asian HC)，WAIS vocabulary score(58．0±7．2 VS 58．0±8．2)，and education(12．9±1．3 VS 13．2±1．7 years)were recruited under an InstitutionalReview Board approved protocol．