Purpose: This study tries to uncover the mechanism of human oralfacial fibro-osseous disease and develop animal model in vivo based on iPSCs derived from patient-specific mesenchymal stem cells.Methods: Ossifyng fibroma(OF)is taken as an example of oralfacial fibro-osseous disease.Primary mesenchymal stem cells were cultured from surgically resected OF samples,the differentiation,proliferationetc were compared with normal jawbone MSC(JMSC).Global geneprofile of OFMSC and JMSC were compared using microarray and cluster analysis.Elisa and westernblot were performed to verify the result from microarray and ingenuity pathway analysis.iPSCs reprogrammed from OFMSCs were subcutaneously transplanted into immunocompromised mice with hydroxyapatite-tricalcaium phosphate(HA/TCP).