【摘 要】
：
细胞毒类化疗药物临床使用过程中出现的毒副作用及耐药现象严重影响患者的治疗效果及生活质量。名贵中药西洋参是传统补益药材，本课题组通过对西洋参活性成分进行筛选获取对顺铂及阿霉素具有减毒和/或增效的有效组分，并明确其分子机制。研究首次发现拟人参皂苷F11可显著抑制顺铂诱导的大鼠血浆BUN和Cr升高，并明显改善顺铂引起的大鼠肾小管组织病理性改变；上述作用与F11抑制顺铂诱导的肾组织氧化损伤及组织凋亡有关；
【机 构】
：
中国烟台大学分子药理和药物评价省部共建教育部重点实验室
论文部分内容阅读
细胞毒类化疗药物临床使用过程中出现的毒副作用及耐药现象严重影响患者的治疗效果及生活质量。名贵中药西洋参是传统补益药材，本课题组通过对西洋参活性成分进行筛选获取对顺铂及阿霉素具有减毒和/或增效的有效组分，并明确其分子机制。研究首次发现拟人参皂苷F11可显著抑制顺铂诱导的大鼠血浆BUN和Cr升高，并明显改善顺铂引起的大鼠肾小管组织病理性改变；上述作用与F11抑制顺铂诱导的肾组织氧化损伤及组织凋亡有关；同时证实拟人参皂苷F11不影响顺铂抑制Lewis肺癌及B16黑色素瘤小鼠移植瘤生长的活性。
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