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Pyridomycin (PYR) is an antimyeobacterial antibiotic produced by Streptomyces pyridomyceticus NRRL B2517 with several attractive biosynthetic features[1,2].The compound has a novel hetero-cylododecane system composed of four moieties in the Following order:N-3-hydroxypicolinyl-L-threonine,3-(3-Pyridyl)-L-alanine,propionic acid and α-keto-β-methylvaleric acid (Fig.1).Based on previous feeding experiment,with [14C] precursors[3].the biosynthesis of the pyridomycin can be predicted to involve the assembly of the backbone on a NRPS-PKS modular system from N-3-hydroxypicolinyl-L-threonine as the starter unit.