Impacts of lipophilic segment of amphiphilic block copolymers on the activity of P-glycoprotein in M

来源 :2017年第三届岭南国际DMPK论坛 | 被引量 : 0次 | 上传用户:DUOFIPAUT8E
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
P-glycoprotein (P-gp) encoded by multidrug resistance 1 (MDR1) gene is an ATP-dependent drug efflux transporters and is expressed in mammalian and human tissues including liver, kidney, pancreas and intestine.
其他文献
Valproic acid (VPA), is a broad-spectrum antiepileptic drug used for the treatment of generalized or partial seizures and neurological disorders.
会议
The proton-coupled oligopeptide transporter PHT1 (SLC15A4), which facilitates cross-membrane transport of histidine and small peptides from inside the endosomes or lysosomes to cytosol, plays an impor
会议
L-C arnitine is an essential cofactor in the transport of long-chain fatty acids from the cytosol to the mitochondrial matrix where β-oxidation takes place.
会议
Shengxiong glucose injection (SGI), a traditional Chinese medicine injection produced by Guizhou with sales of 1.2 billion per year, is clinically effective and widely used for the treatment of variou
会议
Application of imaging mass spectrometry in drug pharmacokinetics remains challenging due to its weak quantitative capability.
会议
Our previous research demonstrated that paclitaxel-containing extract (HDS-1), derived from Taxus yunnanensis, improved the oral absorption of paclitaxel by 9.7 fold and have potential to develop its
会议
It is well accepted that high-altitude hypoxia (HH) can lead to serious physiological changes or illness. The Qinghai-Tibetan plateau is an important military site in China.
会议
Cholesterol is conventionally considered as a risky factor for atherosclerosis, and currently it is accumulatingly reported that AS progression is contributed to cholesterol(“)s dual roles, especially
会议
mPEG2k-PDLLA2k polymer has been extensively researched for smart delivery system due to its promising advantages, such as small size, "stealth" property of hydrophilic shell, drug targeting to the spe
会议
Glyphosate is one of the most commonly used herbicides worldwide and reported low toxicity to humans.
会议