Region-selective biosynthesis of artemisinic acid glycosides by crown galls of Panax quinquefolium

来源 :中国化学会第十届全国天然有机化学学术会议 | 被引量 : 0次 | 上传用户:crackerking
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Glycosylation of artemisinic acid (AA) was investigated using transgenic crown galls of Panax quinquefolium.Two region-selectively glycosylated products (AA-1 and AA-2) were obtained,involving one new compound (AA-2).Their structures were elucidated to be artemisinic acid β-D-glucopyranosyl ester (AA-1, 19.3%) and artemisinic acid β-D-glucopyranosyl-(2→l)-β-D-glucopyranosyl ester (AA-2, 59.1%) by physicochemical and spectroscopic analyses.
其他文献
Agents that can enhance tumor cell apoptosis have potential for the treatment of cancer.Herein,we report the identification of bigelovii A, a noroleanane-type pentacyclic triterpenoid from Salicornia
会议
A convenient and one-pot synthesis of 2-arylbenzofuran-3-carboxylic acids from (E)-2-(2-bromo-phenyl)-3-phenylacrylic acids via Cu-catalyzed consecutive hydroxylation and aerobic oxidative cycloetheri
会议
Three new ent-pimarane diterpenes, named dumetorumanes A-C (1-3), were isolated from the ethanol extract of Aralia dumetorum, together with three known compounds including ent-pimara-8(14), 15-diene-1
会议
In many reports, triterpenoids have been studied and described as anti-inflammatory and immunomodulatory agents.2α-Hydroxy-3β-acetoxy-lup-20(29)-en-28-oic acid (LUP), a lupane-type triterpenoid, was i
会议
Macranthoside B (MB), a saponin from Lonicera macranthoides, can block cell proliferation and induce cell death in several types of cancer cells, while the precise mechanisms by which MB exerts antica
会议
Constitutive activation of STAT3 has been found in a wide variety of cancers, and it has been validated as an attractive anticancer therapeutic target.STAT3 SH2 domain inhibitors could compete with th
会议
Hyperglycemia can lead to an increase in the level of reactive oxygen species (ROS), which might be a cause of impaired embryo development.Resveratrol (3,5,4-trihydroxystilbene), a natural compound fo
会议
Nine chiral compounds (1-9) were produced by a shark gill-derived fungus Penicillium crustosum AP2T1 in static fermentation, including a new acetylenic compound (1), a new quinazoline alkaloid (2), an
会议
Plasma discharge and chemical induction are both novel and convenient approaches for obtaining new microbial natural products.In our previous study, using a marine fungal strain Aspergillus unguis DLE
会议
Here we review Ge Hongs significant contributions in advancing early stage of Chemistry,Chemical Pharmacology, and Medicine.For example, inspired by alchemist Wei Bo-yangs(魏伯阳) description in 《Zhuoyi
会议