【摘 要】
：
D2 dopamine receptors (DARs) is member of G protein coupled receptors (GPCR) family, coupled to Gi protein to inhibit AC activity and reduce the level of cA
【机 构】
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State Key Laboratory of Drug Research and Department of Pharmacology, Shanghai Institute of Materia
【出 处】
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中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
D2 dopamine receptors (DARs) is member of G protein coupled receptors (GPCR) family, coupled to Gi protein to inhibit AC activity and reduce the level of cAME D2DAR is one of the most validated targets in treatment and drug development of central nervous system (CNS) disease.PSD-95, an abundant component of the post-synaptic density (PSD), belongs to membrane associated guanylate kinase (MAGUK).PSD-95 not only acts as an anchor protein, but also plays an important role in functional regulation.Furthermore, PSD-95 can interact with receptors, ion channels and recruit cytoplasmic signaling molecules to form signaling complexes.We performed immunoprecipitation (IP) assay and the results indicated that PSD-95 interacted with D2DAR through PSD-95 N-terminal.Upon agonist activation, the association between PSD-95 and D2DAR obviously reduced.
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