Objective: Histone modification is an important epigenetic modification,which plays an important role in regulation of gene expression.UTX,a demethylase of H3K27,was first reported in 2007,which has been found to participate in a variety of important biological functions,such as stem cell differentiation,embryonic development,hematopoiesis and cancer.Unfortunately,there is not a research associated with metabolic functions.Our study is to construct a UTX liver-specific knockout mouse and observe its phenotypes about glucose and lipid metabolism under chow diet.