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Objective：Studied the metabolism of Cinnamic Acid in homogenized liver of rats. To screen the CYP450 enzyme，which participate on metabolism of Cinnamic Acid. And then supply the evidence for rational administration. Methods：The content of Cinnamic Acid in homogenized liver was measured by the reversed phase HPLC. Analysis effects of inductors and inhibitors on metabolism of Cinnamic Acid. Results：The metabolic rate of ?NF group，the specific CYP1A inductor，was higher than control group significantly. But，PB and DEX group，the main CYP2B and CYP3A inductor，respectively，had no significant difference among these and control groups. Further more,a-NF，the CYP1A inhibitor，could inhibit metabolism of Cinnamic Acid significantly. Conclusion：CYP1A is the major enzyme in metabolism of Cinnamic Acid. The medicine，which have induct and inhibit effects on CYP1A，may have interaction with Cinnamic Acid.